5Fluorouracil Injection is administered via intravenous route by trained personnel for treatment of various types of cancer It shows effectiveness against colon ovarian stomach pancreatic and cervical cancers This injection contains 5fluououracil as active compound having molecular formula C4H3FN2O2 with molar mass of 130077 gmol It is a thymidylate synthase inhibitor which works by blocking synthesis of nucleoside that is essential for DNA replication 5Fluorouracil Injection can have bioavailability range of 28 to 100 with elimination halflife of about 16 minutes It gets metabolized in liver by CYP enzyme
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Uses
Fluorouracil is used in the treatment of ovarian cancer head and neck cancer cervical cancer testicular cancer breast cancer nonhodgkin lymphoma nhl blood cancer lung cancer bone cancer and urinary bladder cancer
How it works
Fluorouracil interferes with the growth of DNA and RNA of the cancer cells by substituting their building blocks It prevents the cancer cells from growing and multiplying
Common side effects
Nausea Vomiting Weakness Loss of appetite Reduced blood platelets Increased risk of infection Decreased white blood cell count Hair loss Bronchospasm Diarrhoea Esophagitis Stomatitis Inflammation of the mouth Inflammation of the rectum
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